The general public was made aware of the discovery of epigenetics through an article in Time Magazine
The feature article began with the story of an European farming village that endured several years of crop failure and famine. But there were also a couple of extremely plentiful years, during which the inhabitants over-ate and became gluttonous. During the glutton years, some of the children were entering puberty and subsequently got married and had families.
When researchers first looked at this population, they were expecting to find birth defects and inherited deficits from the near starvation conditions that persisted for years. Instead, they discovered that the offspring of the pubescent gluttons had an amazing decrease in lifespan of more than 32 years!
"Once Bygren and his team controlled for certain socioeconomic variations, the difference in longevity jumped to an astonishing 32 years. Later papers using different Norrbotten cohorts also found significant drops in life span and discovered that they applied along the female line as well, meaning that the daughters and granddaughters of girls who had gone from normal to gluttonous diets also lived shorter lives." 
Animal studies have long confirmed the relationship between eating less and longevity (see viewzone article), and it is accepted that over-eating and obesity can shorten an organism's life through diseases such as diabetes and heart attacks. But these outcomes usually are apparent only to the offending organism -- not to their offspring.
The Time Magazine article used this research to illustrate how epigenetics, caused by environmental factors, can have hereditary consequences that ripple through many generations. But there were two important questions that were not addressed: first, why would epigenetics punish the offspring for their ancestor's over-eating by shortening their lifespan? Second, how is it that the offspring of both males and females were effected?
In mammals, the male produces sperm as needed during puberty and so the DNA is subject to environmental effects and presumably epigenetic adaptations. Research has shown, for example, that boys who smoked cigarettes at age 11 had male offspring that were more unhealthy and obese than children of non-smoking fathers. The toxins in cigarette smoke are suspected of altering the genes (Y chromosome) in their sperm . Females, on the other hand, are born with a lifetime supply of eggs that are stored in their ovaries. These unfertilized eggs are complete. Their DNA is already established. Are their eggs still subject to epigenesis?
Let's examine these two questions more carefully.
|The Wrath of Epigenetics...|
Remember the Evolutionary Stable Strategies (ESS) we discussed in Part 1
of this article? The strategies that organisms use for survival all follow a basic law.
The words, "The needs of the many outweigh the needs of the few (or the one)", are found in the motion picture Star Trek: The Wrath of Khan, and were spoken by the character Mr. Spock, and attributed to the Vulcan philosopher Surak. They describe (even better than Dowkins) the operational motive at work in the strategies implemented by epigenetics.
Here's how Dowkins described the same thing:
"By some unspecified mechanism, the animal behaves as if he were following these instructions.
An evolutionarily stable strategy or ESS is defined as a strategy which, if most members of a population adopt it, cannot be bettered by an alternative strategy. It is a subtle and important idea. Another way of putting it is to say that the best strategy for an individual depends on what the majority of the population are doing. Since the rest of the population consists of individuals, each one trying to maximize his own success, the only strategy that persists will be one which, once evolved, cannot be bettered by any deviant individual. Following a major environmental change there may be a brief period of evolutionary instability, perhaps even oscillation in the population. But once an ESS is achieved it will stay: selection will penalize deviation from it . 
In the case of the gluttonous ancestors, their action signalled a danger to the group. Sensing that food was normally scarce, an over-eater would have threatened the survival of offspring if they were allowed to exist beyond their reproductive and child-rearing years. Since the normal life span is well past 60, cutting their lives by 32 years provides assurance that they will replicate. After that they are, to the group, "useless over-eaters."
In the case of the pre-teen smokers, the wisdom of epigenetics is also at work, culling the offspring of those individuals who engage in damaging habits that threaten to spread unhealthy activities within the group. Remember, second-hand smoke is also toxic.
I hope, like me, that you are beginning to see some type of overcontrol and active intervention at work here. These genetic changes are very real and adhere to their mission with intelligence. But we'll have more to say about that later.
The Kindness of Epigenetics...
Not all effects of epigenetics are bad. When a strategy benefits the group, as within a species, genetic changes can be positive. Consider the work of Harvard psychologist William McDougall who spent 15 years training rats how to escape from a tank. His first group of rodents made an average of 200 mistakes before learning the correct way out and being rewarded with food. With successive breeding, McDougall arrived at a generation that could complete the task with only 20 mistakes. He repeated the same experiment many times and felt that he demonstrated that learning could be passed along in genes. 
On the other side of the planet, in Australia, researchers were anxious to replicate McDougall's work and so secured a population of the same species of rats to begin the breeding experiment. To their surprise, the rats could immediately find their way out of the tank in just 20 trials! Further tests demonstrated that this was the new baseline for rats as a species.
There are many such reports, including the case of the 100 monkeys that we described in a recent viewzone article. In each case, positive survival adaptation (i.e. securing food) is transmitted to members of the group or species even if there is no direct genetic inheritance. Yet, because subsequent generations exhibit the new behavior, it seems probable that it is the result of some genetic change which mechanistic theorists are at a loss to explain.
Sex is not a factor...
Although we should expect that male sperm can be affected by the environment, the fact that offspring of gluttonous females had a severely reduced life span is remarkable. It suggets that epigenetic changes can exist within the eggs of a woman's ovaries. Taken together with the fact that the older MZ twins showed changes in DNA code throughout their entire body, this suggests that epigenetics is not a mere accident, mistake or anomaly that happens to a local group of cells. It is systemic. All DNA is changed!
So what could be going on here? We will next examine a theory that expands on the morphogenetic field as a kind of "intelligence" which coordinates the response of a group of organisms to environmental challenges. Because this theory deals with a "field" (action at a distance) it has little empirical support. But keep an open mind and see if it makes sense.
The Morphogenetic Field (again)
On average, every human being consists of approximately 10 trillion cells. Inside each cell there are chemical reactions happening at the rate of more than 100,000 every second!  In every second approximately 10 million cells die. These dead cells must be replaced in a short period of time in order to prevent entropic decay. It cannot be predicted where and when a cell will die, but if the replacement rate is only slightly lower (or higher), the body will disintegrate quickly. A good example of this are the cells that line the intestines, which have an unusually large turnover rate. If the replacement rate should exceed the cell death rate by only a small percent, the body would rapidly die from an obstruction.
Mechanisms such as bio-molecular control or chemical "messengers" are clearly not efficient enough to coordinate this life process. This activity requires a level of organization, coordination and overcontrol that must happen at the speed of light. Viewzone covered this topic extensively in our feature Does DNA Emit Light?.
Rupert Sheldrake, with a PhD in biochemistry from Cambridge, is a fellow of the Institute for Noetic Sciences, founded by former astronaut Edgar Mitchell. In his 1981 book A New Science of Life: Hypothesis of Formative Causation he coined the term "morphogenetic field" for coordinating fields that govern the development and cooperation of living organisms. Sheldrake believed that DNA might actually function like a resonance coil (the double helix even looks a bit like radio coil) and receive instructions from the field.
While this might explain the intra-cellular communication, it does not explain how an organism -- made of trillions of individual cells -- can send and receive information and use this information to create genetic alterations and adaptations. To make this theory plausible, we need to find some organ capable of communicating with every cell in the body, having some type of ion capability (since the methyl and histone molecular "switches" attach and inhibit the genes because of altered ion charges on the DNA) and having the ability to interact with the electromagnetic spectrum to communicate with the so-called morphogenetic field.
The Pineal Gland
The pineal gland is a pea size structure in the brain that, amazingly, meets all of the above requirements needed to interact with the morphogenetic field and effect changes to the genes on a systemic basis.
- It has the richest blood supply of the body, second only to the kidneys [*]. The blood is the only method whereby every cell in the body can be reached -- even those in the ovaries. The pineal gland already functions in this manner as the "master regulator" of day-night rhythms as well as the most significant producer of neurotransmitters like serotonin and melotonin.
- The pineal gland contains calcite piezoelectric crystals which accumulate with age.
"Length dimensions of the crystals varied from 2-3 to about 20 micrometres. These results (referring to various forms of analysis described in detail) and the electron diffraction measurements definitely prove that the microcrystals are calcite. These calcite crystals bear a striking resemblance to the otoconia of the inner ear. The calcite in otoconia has been shown to exhibit piezoelectricity. If piezoelectricity were to exist [in the pineal calcite microcrystals], an electromechanical coupling mechanism to external electromagnetic fields may be possible." 
One of the earliest types of radio was the "crystal set" [right], in which a mineral crystal was made to resonate (by tuning with a "cats whisker") with an incoming radio wave, which is simply an electromagnetic wave, propogating at the speed of light.
Piezoelectric crystals are material that has the ability to generate electric charges when their shape is deformed. You probably have experienced this phenomenon when you lit your barbeque grill. There is usually a spring mounted button that slams a piece of metal against a piezoelectric crystal and sends a spark to the burner, igniting the propane. Piezoelectric is also used in many microphones and guitar pick-ups. The movement of sound waves is enough to cause the crystals to deform, ever so slightly, and the resulting electrical charge is then amplified.
The pineal gland could possibly use its piezoelectric crystals to receive electromagnetic waves, converting the signals to electrical energy. It could also transmit this energy by some kind of resonance. Again, we just do not have enough serious research in this subject, but the existence of some type of interaction between an organism and a field is quite compelling.
The Field of God
Now we really leave solid ground -- and venture off to space.
Taken to its extreme, the existence of cellular fields, organism fields, species fields, etc. seem quite apparent. If we know these fields exist, perhaps there are even more fields which control larger populations of life. Some esoteric literature like The Keys of Enoch speak of a galactic field, capable of organizing and coordinating life and consciousness within the Milky Way . They suggest that genetic evolution is intelligently manipulated by this field, and that the galactic field has been responsible for effecting beneficial and evolutionary changes to our DNA. In fact, the Keys describe what is been called a "system upgrade" that will soon be "downloaded" to humanity by means of this energy field, evolving us to another type of material and spiritual existence.
Some theorists have explained that it is only necessary for the galactic field to communicate one way (i.e. to transmit only) and that the pineal gland will receive the signal and adjust the organism to resonate with it. The idea is that the vibrations of the galactic field evolves life within its realm and does not need feedback from each organism or species that it influences. Others argue that every location in a field is local, so that the interaction between a small pineal gland and the galactic field is very plausible.
Along this line of inquiry, the Cognitive Sciences Laboratory in Palo Alto, California, has discovered a cycle during which ESP practitioners are "more" and "less" accurate in their abilities to "see" or predict events. When scientists examined the accuracy of thousands of ESP predictions, along with documented times these anomalous cognitions took place, the precognative cycle coincided with a specific Local Sidereal Time, or LST. This is the galactic time whereby the center of the Milky Way is used instead of the Sun.
The peak of efficiency was not, however, at galactic "high noon" when the center of our Galaxy is directly overhead. Peak efficiency was repeatedly at 13:30 LST. This would place the center of our Galaxy on the opposite side of the sky, essentially being obscured by the earth. It may or may not be significant but it suggests that some field, with its origins in the Milky Way, is influencing our minds and inhibits psychic abilities. The same has been found for solar radiation and electromagnetic disturbances from the Sun. Psychic abilities seem to be most efficient when these activities are at their minimum.
Perhaps the most interesting idea is to think of God as the originator of the universal field -- the ultimate technique whereby all energy and matter are controlled and maintained. The possibilities are truly amazing.
We started this story with the possum sitting in the tree. The adaptation of this animal shows that, although we really do not fully understand the methods at work, the Darwinian concept of random mutations and millions of years of natural selection is a paradigm whose days are numbered. The techniques of life and matter are now reaching their limits with mechanistic and non-spiritual impositions. Hopefully we will some day realize our role in this unfolding drama and have a better understanding of ourselves and our destiny. Then we will be at play in the field of God.
What are your thoughts?
Back to Viewzone Magazine || Comments?
Back to Viewzone Magazine || Comments?
 Time Magazine
 European Journal of Human Genetics (2006)
 The Selfish Gene, Dowkins, p92
 McDougall (1938), Forth report on a Lamarckian experiment, Brit. J. Psychol. 28, 321-345
 The Real Bioinformatics Revolution: Proteins and Nucleic Acids Singing to One Another? (Paper available at firstname.lastname@example.org)
 Bioelectromagnetics 23:488495 (2002) "Calcite Microcrystals in the Pineal Gland of the Human Brain -- First Physical and Chemical Studies", Baconnier, Lang et al.
 Keys of Enoch, JJ.Hurtal, Key 3-1-3, p469.
 Lauren E. Heystek, Hui-qiang Zhou, Prasad Dande, and Barry Gold, "Control over the Localization of Positive Charge in DNA: The Effect on Duplex DNA and RNA Stability",
J. Am. Chem. Soc., 1998, 120 (46), pp 12165-12166